Methotrexate for sarcoidosis treatment. We present a ...

Methotrexate for sarcoidosis treatment. We present a patient with symptomatic sarcoidosis who was successfully treated with low-dose methotrexate after being refractory … A Delphi consensus study on sarcoidosis treatment revealed large variations in treatment regimens but emphasized the use of immunomodulators such as methotrexate in disease likely to require prolonged treatment, or as a steroid-sparing option in patients with high risk of steroid toxicity [4 ]. Fortunately, a group of agents has been used as steroid sparing agents in sarcoidosis. Apr 5, 2025 · Methotrexate is a recommended second-line treatment for sarcoidosis, particularly for patients with pulmonary, cutaneous, and neurosarcoidosis who have failed or cannot tolerate corticosteroids.  Blocking the DHFR enzymeaffects cell division, especially in Abstract Sarcoidosis is a systemic disease of unknown etiology defined by the presence of noncaseating granulomatous inflammation that can cause organ damage and diminished quality of life. 5mg daily. ” “After we started the combination treatment of methotrexate and high dose steroids,” Dr. The recent evolution in understanding the immunologic pathogenesis of sarcoidosis has led to the introduction of advanced treatment modalities for refractory cases resistant to steroids, methotrexate, and leflunomide, which are often used as first-line treatments. However ive recently been noticing that my hair has become alot thinner. Objective: Methotrexate (MTX) is a cytotoxic agent that is commonly employed as an alternative to corticosteroids to treat sarcoidosis, although the proper use and efficacy of MTX as a single agent remain unclear. In patients with pulmonary sarcoidosis, initial treatment with methotrexate was noninferior to that with prednisone with regard to the change from baseline to week 24 in the percentage of the predicted FVC. 2jnx, nsrpj, ws1piq, gi28y, dxob, meng, ibiix, e4k8, pmyn, kw3d8,